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pentobarbital will lower the extent or result of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Sturdy CYP3A4 inducers might minimize midostaurin concentrations leading to lowered efficacy.pentobarbital raises effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Ca